发给老马备查:
7 b2 u& _' I6 ?# D滴水察海(69304838) 15:23:23
" Q6 l0 f! @0 T9 p老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
) f1 W) F& S1 j x2 t/ ]吉非替尼和S-1连用的依据; e2 P, f+ n4 H+ ?: s6 {
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.& u6 X, {( e5 }' o% m, n9 Z
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达& @/ m* E# ]* l$ a
这样是不是推理出,耐药后,可以用S-1和培美了?
) d( P: ^& _% _+ X/ G结论:
h( g: l- e( H" d4 o如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |