发给老马备查:' Y- i5 K: ~( u2 l2 i6 W& d
滴水察海(69304838) 15:23:23
: Z4 u7 R7 @( b/ k# q9 X+ d老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
, }3 D! p; Q8 q8 O2 R吉非替尼和S-1连用的依据, k6 q; E) `* T$ l* N9 `
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
2 j3 L7 e% j1 e- @7 a& W是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
, p; i4 U/ q. \这样是不是推理出,耐药后,可以用S-1和培美了?
9 U! Q+ E0 N+ P结论:
3 I" U. c) Q; j, x s8 x( u6 L如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |