看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
& k. v4 c0 |. w; i. q6 _4 d0 H; |1 v4 I! o& ?4 w6 `5 J4 ^
% r+ l7 L- q |2 e" Q6 CCurrently available feasibility data for possible combination strategies.
) y& o/ `- s( H: m7 L7 p————————————————————————————————
6 [4 W d; h- d! B! M* aCombination Feasibility according to preliminary data : O$ T# B1 I* z( m
——————————————————————————————————
8 \2 l* i5 C- f7 @Bevacizumab + sorafenib Yes, reduced dose 8 K7 H" G0 F. o$ k
Bevacizumab + sunitinib† No
8 G. ]2 s# E+ C- PBevacizumab + temsirolimus Yes D8 ]$ ]$ j- X! X# i% s. q4 @
Bevacizumab + everolimus Yes . ]; ], a" v2 T u- e7 Q7 X6 J( g
Sorafenib + sunitinib ? 2 j+ E9 |0 H2 ^2 s4 t d. l
Sorafenib + temsirolimus Yes, reduced dose
3 Q0 X, p( P" B7 CSorafenib + everolimus Yes, reduced dose
/ v4 ]: h/ y! ~6 ZSunitinib + temsirolimus† No
3 { b3 i2 a5 D$ a/ p% ESunitinib + everolimus ? 9 k5 Z4 ~. F# v: L
Temsirolimus + everolimus ? " H* c0 ^' {7 J0 h: L3 i
————————————————————. Y9 _" p& E- u
†Led to US FDA warning.
" i) a5 t; K' M1 [" D( a?: As yet unattempted combination.
8 o4 b/ a4 X' ~. N) c; ]0 N |